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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Molecular and Chemical Life Science :Multilevel Biomolecular Structure and Dynamics Research HOME Research Researcher JAPANESE Professor MIZUKAMI Shin Campus Katahira campus Laboratory Biofunctional Chemistry and Nanobiotechnology Tel +81-22-217-5116 E-mail shin.mizukami.a6＠tohoku.ac.jp Website http://www2.tagen.tohoku.ac.jp/lab/mizukami/ I was born in Tokyo, and grew up in Kanto region. After studying in US (California), I returned to Kansai region in Japan and started my academic career. Since I was fascinated by the interest and beauty of “chemistry”, especially “organic chemistry”, I investigated with the motivation to understand life by using original chemical approaches. As my ultimate objective, I hope to our bioanalytical tools to develop novel drugs or medical technologies. Career 1997 Univ of Tokyo: B.S. 2002 Univ of Tokyo: Ph.D. (Development of fluorescent seosors for anions that works in aqueous solution; Thesis advisor: Prof. Tetsuo Nagano). 2002-2004 National Institute of Advanced Industrial Science and Technology (AIST): AIST Postdoctoral Fellow 2002-2005 Stanford Univ, Dept of Chemistry: JSPS Postdoctoral Fellow for Research Abroad 2005-2009 Osaka Univ, Grad School of Engineering: Assistant Professor 2009-2016 Osaka Univ, Grad School of Engineering: Associate Professor 2009-2016 Osaka Univ, Immunology Frontier Research Center (IFReC): Associate Professor 2016-present Tohoku University, Institute of Multidisciplinary Research for Advanced Materials (IMRAM):  Professor Selected Publications Enzyme-Triggered Compound Release using Functionalized Antimicrobial Peptide Derivatives S. Mizukami, M. Kashibe, K. Matsumoto, Y. Hori, K. Kikuchi Chem. Sci.  2017, 8, 3047–3053. Real-Time Intravital Imaging of pH Variation Associated with Osteoclast Activity H. Maeda, T. Kowada, J. Kikuta, M. Furuya, M. Shirazaki, S. Mizukami, M. Ishii, K. Kikuchi Nat. Chem. Biol.  2016, 12, 579–585. An Enzyme-Responsive Metal-Enhanced Near-Infrared Fluorescence Sensor Based on Functionalized Gold Nanoparticles Z. Zeng, S. Mizukami, K. Fujita, K. Kikuchi Chem. Sci.  2015, 6, 4934–4939. Activatable 19F MRI Nanoparticle Probes for the Detection of Reducing Environments T. Nakamura, H. Matsushita, F. Sugihara, Y. Yoshioka, S. Mizukami, K. Kikuchi Angew. Chem. Int. Ed.  2015, 54, 1007–1010. Multifunctional Core-shell Silica Nanoparticles for Highly Sensitive 19F Magnetic Resonance Imaging H. Matsushita, S. Mizukami, F. Sugihara, Y. Nakanishi, Y. Yoshioka, K. Kikuchi Angew. Chem. Int. Ed.  2014, 53, 1008–1011. Small-Molecule Based Protein-Labeling Technology in Live Cell Studies: Probe-Design Concepts and Applications S. Mizukami, Y. Hori, K. Kikuchi Acc. Chem. Res.  2014, 47, 247–256. No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis S. Mizukami, S. Watanabe, Y. Akimoto, K. Kikuchi J. Am. Chem. Soc.  2012, 134, 1623–1629. Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-Based Multicolor Bioimaging S. Mizukami, T. Yamamoto, A. Yoshimura, S. Watanabe, K. Kikuchi Angew. Chem. Int. Ed.  2011, 50, 8750–8752. Photocontrolled Compound Release System Using Caged Antimicrobial Peptide S. Mizukami, M. Hosoda, T. Satake, S. Okada, Y. Hori, T. Furuta, K. Kikuchi J. Am. Chem. Soc. 2010, 132, 9524–9525. Activities in Academic Societies Chemical Society of Japan, Pharmaceutical Society of Japan, Japanese Society for Chemical Biology, Japanese Society for Molecular Imaging, American Chemical Society Teaching Advanced Lecture on Biomolecular Sciences, Advanced Biochemistry, Advanced Lecture on Biofunctional Chemistry III Recent Activities When we want to investigate something, we first observe it, then touch and handle it. If we use light and adequate photoresponsive functional molecules, even intracellular biomolecule can be noninvasively observed and manipulated. For such studies, we are developing functional compouonds such as fluorescent probes or photoresponsive peptide tools. Message to Students Chemistry can produce new materials with various functions. If you want to depict your idea in designing new molecules, to observe the behaviors of invisible biomolecules, to regulate biomolecular or cellular functions with molecules and light, or to study both life science and chemistry, or if you have any interest in our research, please feel free to contact us! 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