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ASHBi Institute for the Advanced Study of Human Biology Kyoto University Institute for the Advanced Study of Human Biology MENU About ASHBi Vision & Mission Organization Members Facilities Associated Organizations Life at ASHBi ASHBi Diversity, Equity, Inclusion Committee About ASHBi Vision & Mission Organization Members Facilities Associated Organizations Life at ASHBi ASHBi Diversity, Equity, Inclusion Committee Research Research Groups Flagship Research Project --> Interdisciplinary Research Collaboration with Clinical Researchers --> Technology Development --> Publications Research Research Groups Flagship Research Project --> Interdisciplinary Research Collaboration with Clinical Researchers --> Technology Development --> Publications Core Facility Research Core Facility Equipment SignAC Core Facility Research Core Facility Equipment SignAC AcceleratingResearch ASHBi Office Research Acceleration Programs Overseas Researcher Supports Industry-Academic Cooperation (First Contact Program) Public Relations/Outreach Accelerating Research ASHBi Office Research Acceleration Programs Overseas Researcher Supports Industry-Academic Cooperation (First Contact Program) Public Relations/Outreach News &Events News Events Human Biology Meetings by Others News & Events News Events Human Biology Meetings by Others Careers Work at ASHBi Study at ASHBi Careers Work at ASHBi Study at ASHBi Archive Archive Access Search Internal information 日本語 Home Research Publications Access Search 日本語 English Publications Alev Group Amemori Group Bourque Group Ema Group Fujita Group Hiiragi Group Hiraoka Group Isa Group Murakawa Group Ogawa Group Saitou Group Ueno Group R. Yamamoto Group T. Yamamoto Group Yanagita Group Saitou Group 2022 2021 2020 2019 2022 Original Articles Gyobu-Motani, S., Yabuta, Y., Mizuta, K., Katou, Y., Okamoto, I., Kawasaki, M., Kitamura, A., Tsukiyama, T., Iwatani, C., Tsuchiya, H., Tsujimura, T., Yamamoto, T., Nakamura, T., &＃038; Saitou, M. (2023). Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys. Embo Journal. doi:10.15252/embj.2022112962 Imoto, Y., Nakamura, T., Escolar, E. G., Yoshiwaki, M., Kojima, Y., Yabuta, Y., Katou, Y., Yamamoto, T., Hiraoka, Y., &＃038; Saitou, M. (2022). Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis. Life Science Alliance, 5(12). doi:10.26508/lsa.202201591 Ishikura, Y., Ohta, H., Nagano, M., &＃038; Saitou, M. (2022). Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells. STAR Protoc, 3(3), 101544. doi:10.1016/j.xpro.2022.101544 Mizuta, K., Katou, Y., Nakakita, B., Kishine, A., Nosaka, Y., Saito, S., Iwatani, C., Tsuchiya, H., Kawamoto, I., Nakaya, M., Tsukiyama, T., Nagano, M., Kojima, Y., Nakamura, T., Yabuta, Y., Horie, A., Mandai, M., Ohta, H., &＃038; Saitou, M. (2022). Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys. Embo Journal, 41(18). doi:10.15252/embj.2022110815 Nagano, M., Hu, B., Yokobayashi, S., Yamamura, A., Umemura, F., Coradin, M., Ohta, H., Yabuta, Y., Ishikura, Y., Okamoto, I., Ikeda, H., Kawahira, N., Nosaka, Y., Shimizu, S., Kojima, Y., Mizuta, K., Kasahara, T., Imoto, Y., Meehan, K., Stocsits, R., Wutz, G., Hiraoka, Y., Murakawa, Y., Yamamoto, T., Tachibana, K., Peters, J. M., Mirny, L. A., Garcia, B. A., Majewski, J., &＃038; Saitou, M. (2022). Nucleome programming is required for the foundation of totipotency in mammalian germline development. Embo Journal, 41(13). doi:10.15252/embj.2022110600 Page top 2021 Original Papers Kojima, Y., Yamashiro, C., Murase, Y., Yabuta, Y.,Okamoto, I., Iwatani, C., Tsuchiya, H., Nakaya, M., Tsukiyama, T., Nakamura, T., Yamamoto, T., & Saitou, M. (2021). GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program. Life Sci Alliance, 4(5). https://doi.org/10.26508/lsa.202000974 Io, S., Kabata, M., Iemura, Y., Semi, K., Morone, N., Minagawa, A., Wang, B., Okamoto, I., Nakamura, T., Kojima, Y., Iwatani, C., Tsuchiya, H., Kaswandy, B., Kondoh, E., Kaneko, S., Woltjen, K., Saitou, M., Yamamoto, T., Mandai, M., & Takashima, Y. (2021). Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. https://doi.org/10.1016/j.stem.2021.03.013 Review Articles Nagaoka, SI, Saitou, M, & Kurimoto, K. (2021).Reconstituting oogenesis in vitro: recent progress and future prospects. Current Opinion in Endocrine and Metabolic Research. Saitou, M. (2021). Mammalian germ cell development: from mechanism to in vitro reconstitution. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2021.01.008 Page top 2020 Original Papers Matsumoto, S., Porter, C. J., Ogasawara, N., Iwatani, C., Tsuchiya, H., Seita, Y., Chang, Y. W., Okamoto, I., Saitou, M., Ema, M., Perkins, T. J., Stanford, W. L., & Tanaka, S. (2020). Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-63602-7 Murase, Y., Yabuta, Y., Ohta, H., Yamashiro, C., Nakamura,T., Yamamoto, T., & Saitou, M. (2020). Long-term expansion with germline potential of human primordial germ cell-like cells in vitro. Embo Journal, 39(21). https://doi.org/10.15252/embj.2020104929 Nagaoka, S. I., Nakaki, F., Miyauchi, H., Nosaka, Y.,Ohta, H., Yabuta, Y., Kurimoto, K., Hayashi, K., Nakamura, T., Yamamoto, T.,& Saitou, M. (2020). ZGLP1 is a determinant for the oogenic fate in mice. Science, 367(6482), 1089-+. https://doi.org/10.1126/science.aaw4115 Ohta, H, Yabuta, Y, Kurimoto, K, Nakamura, T, Murase, Y, Yamamoto,T, & Saitou, M. (2020). Cyclosporin A and FGF signaling supportthe proliferation/survival of mouse primordial germ cell-like cells in vitro. Biology of Reproduction. https://doi.org/10.1093/biolre/ioaa195 Sakai, Y., Nakamura, T., Okamoto, I., Gyobu-Motani, S., Ohta, H., Yabuta, Y., Tsukiyama, T., Iwatani, C., Tsuchiya, H., Ema,M., Morizane, A., Takahashi, J., Yamamoto, T., & Saitou, M. (2020). Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys. Biology of Reproduction, 102(3), 620-638. https://doi.org/10.1093/biolre/ioz205 Yamashiro, C., Sasaki, K., Yokobayashi, S., Kojima, Y.,& Saitou, M. (2020). Generation of human oogonia from induced pluripotent stem cells in culture. Nature Protocols, 15(4), 1560-1583. https://doi.org/10.1038/s41596-020-0297-5 Matsumoto, S., Porter, C. J., Ogasawara, N., Iwatani, C.,Tsuchiya, H., Seita, Y., Chang, Y. W., Okamoto, I., Saitou, M., Ema, M., Perkins, T. J., Stanford, W. L., & Tanaka, S. (2020). Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-63602-7 Page top 2019 Original Paper Mutzel, V., Okamoto, I., Dunkel, I., Saitou, M., Giorgetti, L., Heard, E., &Schulz, E. G. (2019). A symmetric toggle switch explains the onset of random Xinactivation in different mammals. Nature Structural & Molecular Biology, 26(5), 350-+. https://doi.org/10.1038/s41594-019-0214-1 Review Article Kurimoto, K., & Saitou, M. (2019). Germ cell reprogramming. In R. Lehmann (Ed.), ImmortalGermline (Vol. 135, pp. 91-125). Page top Alev Group Amemori Group Bourque Group Ema Group Fujita Group Hiiragi Group Hiraoka Group Isa Group Murakawa Group Ogawa Group Saitou Group Ueno Group R. Yamamoto Group T. Yamamoto Group Yanagita Group About ASHBi Vision & Mission Organization Members Facilities Associated Organizations Life at ASHBi ASHBi Diversity, Equity, Inclusion Committee Research Research Groups Flagship Research Project--> Interdisciplinary Research Collaboration with Clinical Researchers --> Technology Development --> Publications Core Facility Research Core Facility Equipment SignAC Accelerating Research ASHBi Office Research Acceleration Programs Overseas Researcher Support Industry-Academic Cooperation (First Contact Program) Public Relations/Outreach News & Events News Events Human Biology Meetings by Others Careers Work at ASHBi Study at ASHBi Archive Internal information ASHBi Institute for the Advanced Study of Human Biology Contact Institute for the Advanced Study of Human Biology (ASHBi) Faculty of Medicine Bldg. 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